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Flexeril is modestly effective for acute lower back pain with muscle spasm, although efficacy begins to decrease after about 4 days

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It retains the core pharmacophore (His-Phe-Arg-Trp), incorporates a D-Phe substitution, and forms a cyclic lactam bridge, resulting in a 7-amino-acid cyclic peptide with a molecular weight of approximately 1024.2 Da